The iScreen™ OFD (Oral Fluid Device) is a lateral flow chromatographic immunoassay for the qualitative detection of cotinine, the primary metabolite of nicotine. This device simplifies the collection process and protects against specimen tampering by allowing observed collection anywhere and anytime. With a detection window of up to 1–2 days after nicotine use, it provides a reliable determination of smoking status without the need for specialized laboratory equipment.