Airway Clearance Therapy in Chronic Lung Care
In chronic lung disease, mucus can accumulate in the airways due to inflammation, structural airway changes, or reduced cough effectiveness. When mucus is not cleared efficiently, it can restrict airflow, reduce oxygen exchange, and provide an environment that supports bacterial growth.
Over time, persistent mucus retention may lead to repeated infections, airway inflammation, and progressive lung damage. For this reason, airway clearance therapy is typically prescribed as part of long-term respiratory disease management rather than as a short-term intervention.

Why Is Airway Clearance Therapy Clinically Important?
Excess mucus plays a central role in disease progression for many chronic respiratory conditions. Thick or sticky secretions can block airways, trap bacteria, and lead to continuing inflammation.
Without regular clearance, mucus buildup may lead to structural airway changes, such as dilation or scarring. This cycle increases the likelihood of exacerbations, hospital admissions, and long-term decline in lung function. Regular airway clearance therapy helps reduce mucus burden and supports more stable respiratory health.
Clinical Benefits of Airway Clearance Therapy
Clinical research and long-term practice indicate that consistent airway clearance therapy may provide the following benefits:
- Reduced mucus retention, helping keep airways more open
- Lower frequency of respiratory infections in chronic conditions
- Improved airflow and breathing comfort
- Support to sustain lung function over time
These outcomes are why professional respiratory organizations recommend airway clearance as part of individualized treatment plans for many chronic lung diseases.
What Does Airway Clearance Therapy Include?
Airway clearance therapy includes a range of techniques designed to assist patients whose cough strength, airway structure, or lung function is insufficient to remove mucus independently. These techniques may involve:
- Breathing exercises that improve airflow
- Assisted coughing techniques
- Mechanical devices that apply external forces to the chest wall
Although methods differ, the clinical objective remains the same: improving mucus movement and clearance.
Evidence-Based Outcomes of Airway Clearance Therapy
Studies comparing airway clearance therapy with no treatment consistently indicate greater sputum clearance and better symptom control. In some patient populations, regular ACT has been associated with stabilization or modest improvement in lung function measures such as forced expiratory volume in one second (FEV₁).
Additional findings include fewer acute respiratory exacerbations and improved ability to carry out everyday tasks. Because disease severity and response vary, clinical guidelines recommend selecting airway clearance methods based on each patient's needs rather than a single standardized approach.
Common Airway Clearance Techniques
Active Cycle of Breathing Technique (ACBT)
A structured breathing sequence that combines relaxed breathing, deep breathing, and controlled coughing to mobilize mucus.
Positive Expiratory Pressure (PEP) Therapy
A technique that involves breathing out against resistance to help keep airways open and move secretions.
Postural Drainage with Percussion
A traditional approach that uses gravity and manual chest percussion to assist mucus movement.
High Frequency Chest Wall Oscillation (HFCWO)
A device-based method that uses rapid chest wall vibrations to loosen and mobilize lung mucus.
Portable HFCWO airway clearance vests are often selected for patients who require consistent, long-term therapy and prefer a standardized, independent method.
Summary: Clinical Role of Airway Clearance Therapy
Airway clearance therapy is a basic part of care for many chronic respiratory conditions. By helping remove excess mucus, ACT helps reduce infection risk, improve breathing comfort, and promote ongoing lung function.
Portable HFCWO systems, such as the AffloVest® Airway Clearance Vest System, represent one clinically used method for delivering airway clearance therapy in home and non-clinical settings. When prescribed and monitored appropriately, these devices support consistent therapy as part of an individualized respiratory care plan.